Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease.

@article{Stott2005RandomizedCT,
  title={Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease.},
  author={David Stott and G Macintosh and Gordon D. O. Lowe and Ann Rumley and Alex D. McMahon and Peter Langhorne and R Campbell Tait and Denis St J O'Reilly and Edward G Spilg and J. B. Macdonald and Peter W Macfarlane and Rudi G. J. Westendorp},
  journal={The American journal of clinical nutrition},
  year={2005},
  volume={82 6},
  pages={1320-6}
}
BACKGROUND Homocysteine is an independent risk factor for vascular disease and is associated with dementia in older people. Potential mechanisms include altered endothelial and hemostatic function. OBJECTIVE We aimed to determine the effects of folic acid plus vitamin B-12, riboflavin, and vitamin B-6 on homocysteine and cognitive function. DESIGN This was a factorial 2 x 2 x 2, randomized, placebo-controlled, double-blind study with 3 active treatments: folic acid (2.5 mg) plus vitamin B… CONTINUE READING