Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

@article{Thiboutot2001RandomizedCT,
  title={Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.},
  author={D M Thiboutot and Michael H Gold and Michael T Jarratt and Soowhan Kang and David L. Kaplan and Larry Edward Millikan and James Wolfe and Christian Loesche and Meghan Baker},
  journal={Cutis},
  year={2001},
  volume={68 4 Suppl},
  pages={
          10-9
        }
}
A prior meta-analysis of 5 randomized controlled trials indicates that adapalene gel 0.1% is as effective as tretinoin gel 0.025% against acne and has greater tolerability. To determine the tolerability and efficacy of adapalene gel 0.1% versus tretinoin microsphere gel 0.1% in 168 patients with acne vulgaris, we conducted a 12-week, multicenter, randomized, controlled, investigator-masked, parallel-group design study. Efficacy variables included noninflammatory, inflammatory, and total lesion… CONTINUE READING

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