Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty.

@article{Byren2012RandomizedCT,
  title={Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty.},
  author={Ivor Byren and Shruta Rege and Ed Campanaro and Sara Yankelev and Diane Anastasiou and Gennady Kuropatkin and Richard Evans},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 11},
  pages={5626-32}
}
The prevalence of Staphylococcus aureus causing prosthetic joint infection (PJI) supports investigation of higher doses of daptomycin in the management of PJI. This was a prospective, randomized controlled trial studying safety and efficacy of daptomycin (6 and 8 mg/kg of body weight) compared with standard-of-care therapy for PJI. This open-label study… CONTINUE READING