Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1).

@article{Jones2006RandomizedCT,
  title={Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1).},
  author={Peter B. Jones and Thomas R. E. Barnes and Linda J Davies and G. Dunn and Helen Buckie Lloyd and K P Hayhurst and Robin MacGregor Murray and Alison Markwick and Sh{\^o}n William Lewis},
  journal={Archives of general psychiatry},
  year={2006},
  volume={63 10},
  pages={1079-87}
}
CONTEXT Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer adverse effects, and preferable to patients. Most evidence comes from short-term efficacy trials of symptoms. OBJECTIVE To test the hypothesis that in people with schizophrenia requiring a change in treatment, SGAs other than clozapine are associated with improved quality of life across 1 year compared with FGAs… CONTINUE READING
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