Randomized controlled trial of dexamethasone treatment in very-low-birth-weight infants with ventilator-dependent chronic lung disease.

@article{Ohlsson1992RandomizedCT,
  title={Randomized controlled trial of dexamethasone treatment in very-low-birth-weight infants with ventilator-dependent chronic lung disease.},
  author={Arne Ohlsson and Sandra Calvert and Martin Charles Kenneth Hosking and Andrew T. Shennan},
  journal={Acta paediatrica},
  year={1992},
  volume={81 10},
  pages={751-6}
}
This randomized controlled trial was designed to answer the question: does administration of dexamethasone to neonates with bronchopulmonary dysplasia decrease the need for assisted ventilation? Twenty-five infants with a birth weight < 1501 g, requiring mechanical ventilation and FiO2 of > or = 0.30 at 21-35 days of age, were randomized to treatment with iv dexamethasone or to sham injections for 12 days. The primary outcome criterion was extubation within seven days after study entry… CONTINUE READING