Randomized consent designs for clinical trials: an update.

  title={Randomized consent designs for clinical trials: an update.},
  author={Marvin Zelen},
  journal={Statistics in medicine},
  volume={9 6},
Randomized consent designs were introduced to make it easier for physicians to enter patients in randomized clinical trials. Physician reluctance to participate in randomized clinical trials is often a reflection that the physician-patient relationship could be compromised if the physician makes known to the patient his/her inability to select a preferred therapy. Clinical trials having a no-treatment control or placebo amplify this concern. This paper reviews the main ideas of randomized… CONTINUE READING