Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial.

@article{Kempen2011RandomizedCO,
  title={Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial.},
  author={John H Kempen and Michael M. Altaweel and Janet T Holbrook and Douglas A. Jabs and Thomas A. Louis and Elizabeth A. Sugar and Jennifer E. Thorne},
  journal={Ophthalmology},
  year={2011},
  volume={118 10},
  pages={1916-26}
}
OBJECTIVE To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated (systemic therapy) versus fluocinolone acetonide implant (implant therapy) for noninfectious intermediate, posterior, or panuveitis (uveitis). DESIGN Randomized controlled parallel superiority trial. PARTICIPANTS Patients with active or recently active uveitis. METHODS Participants were randomized (allocation ratio 1:1) to systemic or implant therapy at 23 centers (3 countries… CONTINUE READING

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Randomized comparison of systemic anti - inflammatory therapy versus fluocinolone acetonide implant for intermediate , posterior , and panuveitis : the multicenter uveitis steroid treatment trial . OBJECTIVE .
Over the 24 month period , implant - assigned eyes had a higher risk of cataract surgery ( 80% , hazard ratio [ HR ] = 3.3 , P < 0.0001 ) , treatment for elevated intraocular pressure ( 61% , HR=4.2 , P < 0.0001 ) , and glaucoma ( 17% , HR=4.2 , P = 0.0008 ) .
Over the 24 month period , implant - assigned eyes had a higher risk of cataract surgery ( 80% , hazard ratio [ HR ] = 3.3 , P < 0.0001 ) , treatment for elevated intraocular pressure ( 61% , HR=4.2 , P < 0.0001 ) , and glaucoma ( 17% , HR=4.2 , P = 0.0008 ) .
Randomized comparison of systemic anti - inflammatory therapy versus fluocinolone acetonide implant for intermediate , posterior , and panuveitis : the multicenter uveitis steroid treatment trial . OBJECTIVE .
To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated ( systemic therapy ) versus fluocinolone acetonide implant ( implant therapy ) for noninfectious intermediate , posterior , or panuveitis ( uveitis ) .
Randomized comparison of systemic anti - inflammatory therapy versus fluocinolone acetonide implant for intermediate , posterior , and panuveitis : the multicenter uveitis steroid treatment trial . OBJECTIVE .
To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated ( systemic therapy ) versus fluocinolone acetonide implant ( implant therapy ) for noninfectious intermediate , posterior , or panuveitis ( uveitis ) .
To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated ( systemic therapy ) versus fluocinolone acetonide implant ( implant therapy ) for noninfectious intermediate , posterior , or panuveitis ( uveitis ) .
Randomized comparison of systemic anti - inflammatory therapy versus fluocinolone acetonide implant for intermediate , posterior , and panuveitis : the multicenter uveitis steroid treatment trial . OBJECTIVE .
UveitisParent is nichdPanuveitis
To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated ( systemic therapy ) versus fluocinolone acetonide implant ( implant therapy ) for noninfectious intermediate , posterior , or panuveitis ( uveitis ) .
Randomized comparison of systemic anti - inflammatory therapy versus fluocinolone acetonide implant for intermediate , posterior , and panuveitis : the multicenter uveitis steroid treatment trial . OBJECTIVE .
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