Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study.

@article{Post2010RandomizedCO,
  title={Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study.},
  author={Frank A. Post and Graeme J. Moyle and Hans J{\"u}rgen Stellbrink and Pere Domingo and Daniel Podzamczer and Martin Fisher and Anthony G. W. Norden and Matthias Cavassini and Armin C Rieger and Marie-Aude Khuong-Josses and Teresa Branco and Helen C Pearce and Naomi Givens and Cindy L Vavro and Michael Lim},
  journal={Journal of acquired immune deficiency syndromes},
  year={2010},
  volume={55 1},
  pages={
          49-57
        }
}
BACKGROUND Abacavir/lamivudine and tenofovir/emtricitabine fixed-dose combinations are commonly used first-line antiretroviral therapies, yet few studies have comprehensively compared their safety profiles. METHODS Forty-eight-week data are presented from this multicenter, randomized, open-label study comparing the safety profiles of abacavir/lamivudine and tenofovir/emtricitabine, both administered with efavirenz, in HLA-B*5701-negative HIV-1-infected adults. RESULTS Three hundred eighty… CONTINUE READING

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