Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy.

@article{McGready2000RandomizedCO,
  title={Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy.},
  author={Rose McGready and Alan Brockman and Thein Cho and Daniel Y Cho and Mich{\`e}le van Vugt and Christine Luxemburger and Tan Chongsuphajaisiddhi and Nicholas J White and François H Nosten},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  year={2000},
  volume={94 6},
  pages={689-93}
}
Since no effective malaria prevention measures have been identified for pregnant women living on the western border of Thailand, prompt diagnosis and efficient treatment are paramount, although drug resistance in Plasmodium falciparum has narrowed the treatment options. An open randomized comparison of supervised quinine (10 mg salt/kg every 8 h) for 7 days (Q7) versus mefloquine 25 mg base/kg (total dose) plus artesunate 4 mg/kg per day for 3 days (MAS3) was conducted in 1995-97 in 108 Karen… CONTINUE READING

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