Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.

@article{Mayxay2004RandomizedCO,
  title={Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.},
  author={Mayfong Mayxay and Maniphone Khanthavong and Niklas Lindeg{\aa}rdh and Siamphay Keola and Marion Barends and Tiengkham Pongvongsa and Ratsuda Yapom and Anna Annerberg and Samalane Phompida and Rattanaxay Phetsouvanh and Nicholas J White and Paul N Newton},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2004},
  volume={39 8},
  pages={
          1139-47
        }
}
BACKGROUND Recent clinical trials in the Lao People's Democratic Republic have demonstrated that chloroquine and sulfadoxine-pyrimethamine, which are national malaria treatment policy, are no longer effective in the treatment of uncomplicated Plasmodium falciparum malaria. METHODS A randomized comparison of 3 oral antimalarial combinations--chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine--with 42-day follow-up period, was conducted… CONTINUE READING

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