Randomized clinical trial with alpha 2b-interferon in 26 stage A untreated B-chronic lymphocytic leukemia patients.

Abstract

In a previous study we obtained a 50% response rate with alpha 2b Interferon in the first stages of chronic lymphocytic leukaemia. We have performed a second study randomizing 34 stage A patients, who were receiving no other treatment (8 non-treated controls and 26 patients who had been treated with 3 modalities). We obtained 17 responses (67%) with one complete haematological response (4%), 9 incomplete (34%) and 7 minor (37%). No bone marrow changes were noted after this treatment but there was a decrease in the lymph nodes or the spleen seen on three occasions. In a new randomised study we have studied the effects of the small doses of Interferon associated with chemotherapy.

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@article{Boussiotis1988RandomizedCT, title={Randomized clinical trial with alpha 2b-interferon in 26 stage A untreated B-chronic lymphocytic leukemia patients.}, author={Viki A. Boussiotis and G. A. Pangalis}, journal={Nouvelle revue francaise d'hematologie}, year={1988}, volume={30 5-6}, pages={471-3} }