Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV‐1 in Tanzania

  title={Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV‐1 in Tanzania},
  author={Wafaie W. Fawzi and Genard Msamanga and David J. Hunter and Ernest J.N. Urassa and Boris Renjifo and Davis Mwakagile and Ellen Hertzmark and Jenny Coley and Miriam Garland and Saidi Kapiga and Gretchen Antelman and Max Essex and Donna Spiegelman},
  journal={JAIDS Journal of Acquired Immune Deficiency Syndromes},
Background: Observational studies suggest that poor nutritional status among HIVinfected pregnant women is associated with a higher risk of vertical transmission of HIV. Methods: We randomized 1083 pregnant women infected with HIV‐1 in a doubleblind, placebo‐controlled trial to examine the effects of supplements of vitamin A and/or multivitamins (excluding vitamin A) using a 2‐x‐2 factorial design. We report the effects of the supplements on HIV infection defined using polymerase chain reaction… Expand
Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Multivitamin (B, C, and E) supplementation of breastfeeding mothers reduced child mortality and HIV-1 transmission through breastfeeding among immunologically and nutritionally compromised women. Expand
Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trial.
A randomized, double-blind, placebo-controlled trial of 6 weeks of daily oral vitamin A (10,000 IU of retinyl palmitate) was conducted among 400 HIV-1-infected women in Mombasa, Kenya, and no effect was seen among women who were vitamin A deficient at baseline. Expand
Effect of vitamin supplementation to HIV-infected pregnant women on the micronutrient status of their infants
Vitamin supplementation to HIV-1-infected women during pregnancy and lactation is effective in improving the vitamin status of infants during the first 6 months of age. Expand
A systematic review of randomized controlled trials of prenatal and postnatal vitamin A supplementation of HIV‐infected women
  • E. Kongnyuy, C. Wiysonge, M. Shey
  • Medicine
  • International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2009
There was no evidence of an effect of prenatal and/or postnatal vitamin A supplementation on the risk of MTCT of HIV, and the available evidence does not support vitamin A supplements of HIV‐infected pregnant and lactating women, despite improvement in birth weight. Expand
Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women
Reducing prematurity, rate of HIV disease progression, and maternal viral load at or after delivery could help to reduce vertical transmission. Expand
Nutritional Factors and Vertical Transmission of HIV‐1 Epidemiology and Potential Mechanisms
  • W. Fawzi
  • Medicine
  • Annals of the New York Academy of Sciences
  • 2000
Findings from randomized, controlled trials suggest that supplements of vitamin A or other vitamins are unlikely to have an effect on vertical transmission during pregnancy or the intrapartum period, and the effect of other nutrient supplements, such as zinc and selenium, is unknown. Expand
Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women
Randomized trials of vitamins to prevent MTCT have yielded conflicting results without strong evidence of benefit and have failed to exclude the possibility of harm. Expand
Multivitamin supplementation improves hematologic status in HIV-infected women and their children in Tanzania.
Multiv vitamin supplementation provided during pregnancy and in the postpartum period resulted in significant improvements in hematologic status among HIV-infected women and their children, which provides further support for the value of multivitamin supplementation in HIV- infected adults. Expand
Micronutrient Supplementation Increases Genital Tract Shedding of HIV-1 in Women: Results of a Randomized Trial
In this randomized trial, micronutrients resulted in higher levels of genital HIV-1 shedding compared with placebo, and the potential benefit of micronUTrient supplementation in HIV- 1-seropositive women should be considered in relation to the potential for increased infectivity. Expand
Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women.
Multivitamin supplementation during pregnancy improves the pattern of weight gain among HIV-infected women and was protective against low weight gain during the second trimester compared with multivitamins alone. Expand