Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.

@article{Saturni2014RandomizedCT,
  title={Randomized Controlled Trials and real life studies. Approaches and methodologies: a clinical point of view.},
  author={Sara Saturni and F Bellini and Fulvio Braido and P Paggiaro and Alessandro Zamparelli Sanduzzi and N Scichilone and Pierachille Santus and L Morandi and A Papi},
  journal={Pulmonary pharmacology & therapeutics},
  year={2014},
  volume={27 2},
  pages={129-38}
}
Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". They are designed to test a therapeutic hypothesis under optimal setting in the absence of confounding factors. For this reason they have high internal validity. The strict and controlled conditions in which they are conducted, leads to low generalizability because they are performed in conditions very different from real life usual care. Conversely, real… CONTINUE READING

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