Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine.

@article{Tohen2006RandomizedPT,
  title={Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine.},
  author={Mauricio Tohen and Joseph R. Calabrese and Gary S. Sachs and Michael D Banov and Holland C. Detke and Richard C Risser and Robert W. Baker and James C-y Chou and Charles L. Bowden},
  journal={The American journal of psychiatry},
  year={2006},
  volume={163 2},
  pages={247-56}
}
OBJECTIVE In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder. METHOD Patients achieving symptomatic remission from a manic or mixed episode of bipolar I disorder (Young Mania Rating Scale [YMRS] total score < or =12 and 21-item Hamilton Depression Rating Scale [HAM-D] score <or =8) at two consecutive weekly visits following 6-12 weeks of open-label acute treatment with 5-20 mg… CONTINUE READING
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