Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer.

@article{Prol2012RandomizedPI,
  title={Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer.},
  author={Maurice P{\'e}rol and Christos Choua{\"i}d and David P{\'e}rol and Fabrice Barl{\'e}si and Radj Gervais and V. Westeel and Jacky Cr{\'e}quit and Herv{\'e} L{\'e}na and Alain Vergnen{\`e}gre and G{\'e}rard Zalcman and Isabelle Monnet and Herve Le Caer and Pierre Fournel and Lionel Falchero and Michel Poudenx and Fabien Vaylet and C{\'e}line S{\'e}gura-Ferlay and Mojgan Devouassoux-Shisheboran and M{\`i}quel Taron and Bernard Milleron},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2012},
  volume={30 28},
  pages={3516-24}
}
PURPOSE This phase III study investigated whether continuation maintenance with gemcitabine or switch maintenance with erlotinib improves clinical outcome compared with observation in patients with advanced non-small-cell lung cancer (NSCLC) whose disease was controlled after cisplatin-gemcitabine induction chemotherapy. PATIENTS AND METHODS Four hundred sixty-four patients with stage IIIB/IV NSCLC without tumor progression after four cycles of cisplatin-gemcitabine were randomly assigned to… CONTINUE READING
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