Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria.

@article{Lwin2012RandomizedDP,
  title={Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria.},
  author={Khin Maung Lwin and Aung Pyae Phyo and Joel Tarning and Warunee Hanpithakpong and Elizabeth A Ashley and Sue J Lee and Phaikyeong Cheah and Pratap Singhasivanon and Nicholas J White and Niklas Lindeg{\aa}rdh and François H Nosten},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 3},
  pages={
          1571-7
        }
}
Intermittent preventive treatment (IPT) is increasingly used to reduce malaria morbidity and mortality in children and pregnant women. The efficacy of IPT depends on the pharmacokinetic and pharmacodynamic properties of the antimalarial drugs used. Healthy adult male volunteers whose occupation put them at high risk of malaria on the Northwest border of Thailand were randomized to receive a 3-day-treatment dose of dihydroartemisinin-piperaquine monthly (DPm) or every 2 months (DPalt) or an… CONTINUE READING
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