Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis.

@article{Nickel2005RandomizedDD,
  title={Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis.},
  author={John Curtis Nickel and Jack Barkin and John Forrest and Phillip G Mosbaugh and Jose M. Hernandez-Graulau and David M Kaufman and Keith Lloyd and Robert J. Evans and C. Lowell Parsons and Linda E Atkinson},
  journal={Urology},
  year={2005},
  volume={65 4},
  pages={654-8}
}
OBJECTIVES To compare the current recommended dose of pentosan polysulfate sodium (PPS) with doses two to three times higher. METHODS We evaluated three dosages (300, 600, and 900 mg) of PPS in a randomized, double-blind, double-dummy, parallel-group, multicenter, 32-week study. Adults (n = 380) with a diagnosis of interstitial cystitis (IC) as determined by a positive cystoscopic examination combined with bladder pain and urgency or a history of IC symptoms for at least 6 months were… CONTINUE READING

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