Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis.

@article{Louwerse1995RandomizedDC,
  title={Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis.},
  author={Elisabeth S. Louwerse and Gerrit Jan Weverling and P M M Bossuyt and F. E. Posthumus Meyjes and J M B Vianney de Jong},
  journal={Archives of neurology},
  year={1995},
  volume={52 6},
  pages={559-64}
}
BACKGROUND Free radicals may play a role in the pathogenesis of amyotrophic lateral sclerosis. OBJECTIVE To investigate the efficacy of the free radical scavenging agent acetylcysteine in patients with amyotrophic lateral sclerosis. DESIGN Randomized, double-blind, placebo-controlled clinical trial to assess the effect of treatment with acetylcysteine on survival and disease progression. SETTING A university hospital referral setting. PATIENTS One hundred ten consecutive patients who… CONTINUE READING

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