Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients

@article{Nathens2002RandomizedPT,
  title={Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients},
  author={Avery B. Nathens and Margaret J. Neff and Gregory J. Jurkovich and Patricia Klotz and Katherine Farver and John T. Ruzinski and Frank A. Radella and Iris A Garc{\'i}a and Ronald V. Maier},
  journal={Annals of Surgery},
  year={2002},
  volume={236},
  pages={814-822}
}
ObjectiveTo determine the effectiveness of early, routine antioxidant supplementation using &agr;-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction in critically ill surgical patients. Summary Background DataOxidative stress has been associated with the development of the acute respiratory distress syndrome (ARDS) and organ failure through direct tissue injury and activation of genes integral to the inflammatory response. In addition, depletion of… 

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