Randomized, Double-Blinded, Placebo-Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery

@inproceedings{Ranucci2015RandomizedDP,
  title={Randomized, Double-Blinded, Placebo-Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery},
  author={Marco Ranucci and Ekaterina Baryshnikova and Giulia Beatrice Crapelli and N Rahe-meyer and Lorenzo A Menicanti and Alessandro Frigiola},
  booktitle={Journal of the American Heart Association},
  year={2015}
}
BACKGROUND Postoperative bleeding after heart operations is still a common finding, leading to allogeneic blood products transfusion. Fibrinogen and coagulation factors deficiency are possible determinants of bleeding. The experimental hypothesis of this study is that a first-line fibrinogen supplementation avoids the need for fresh frozen plasma (FFP) and reduces the need for any kind of transfusions. METHODS AND RESULTS This was a single-center, prospective, randomized, placebo-controlled… CONTINUE READING
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