Randomized, Double-Blind, Placebo-Controlled Study About the Effects of Cannabidiol (CBD) on the Pharmacokinetics of Δ9-Tetrahydrocannabinol (THC) After Oral Application of THC Verses Standardized Cannabis Extract
@article{Nadulski2005RandomizedDP, title={Randomized, Double-Blind, Placebo-Controlled Study About the Effects of Cannabidiol (CBD) on the Pharmacokinetics of $\Delta$9-Tetrahydrocannabinol (THC) After Oral Application of THC Verses Standardized Cannabis Extract}, author={Thomas Nadulski and Fritz Pragst and Gordon Weinberg and Patrik Roser and Martin Schnelle and Eva-Maria Fronk and Andreas M. Stadelmann}, journal={Therapeutic Drug Monitoring}, year={2005}, volume={27}, pages={799-810} }
Cannabidiol (CBD) is known to modify the effects of Delta-tetrahydrocannabinol (THC) by decreasing anxiety and antagonizing other THC-effects. [] Key Method In context of the use of cannabis-based medicine extracts for therapeutic purposes, a study was performed in a double-blind and placebo-controlled cross-over design in which each of 24 volunteers (12 male and 12 female, age 18-45 years) obtained soft-gelatin capsules with 10 mg THC (THC-set), cannabis extract containing 10 mg THC +5.4 mg CBD (CAN-set) or…
115 Citations
Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.
- MedicineCurrent pharmaceutical design
- 2012
In healthy volunteers, THC has marked acute behavioural and physiological effects, whereas CBD has proven to be safe and well tolerated.
Pharmacokinetics of cannabichromene in a medical cannabis product also containing cannabidiol and Δ9-tetrahydrocannabinol: a pilot study.
- Medicine, BiologyEuropean journal of clinical pharmacology
- 2021
CBC may have preferential absorption over CBD and THC when administered together when administering together, and the dose of THC was similar to the doses of CBC, yet THC was quantifiable in fewer plasma samples than was CBC.
Cannabinoid tetrad effects of oral Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in male and female rats: sex, dose-effects and time course evaluations.
- BiologyPsychopharmacology
- 2021
The effects of cannabinoids THC and CBD when administered orally on measures of pain sensitivity, body temperature, locomotor activity, and catalepsy in male and female Sprague Dawley rats were examined.
Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
- Biology, PsychologyPsychopharmacology
- 2011
CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
- MedicineJournal of analytical toxicology
- 2021
A prudent approach to improve tolerability with Spectrum Yellow oil might involve initial doses no higher than 240”mg total CBD and 10.8 mg total THC daily in divided doses, with titration upward over time as needed based on tolerability.
Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition
- Biology, PsychologyPsychopharmacology
- 2019
Cannabis containing equivalent concentrations of CBD and THC appears no less impairing than THC-dominant cannabis, and in some circumstances, CBD may actually exacerbate THC-induced impairment.
Cannabidiol-Δ-tetrahydrocannabinol interactions on acute pain and locomotor activity
- Biology, Psychology
- 2017
The results suggest that CBD may enhance THC’s antinociceptive and hypolocomotive effects, primarily prolonging THC”s duration of action; however, these effects were small and inconsistent across experiments.
Acute and chronic effects of cannabidiol on Δ⁹-tetrahydrocannabinol (Δ⁹-THC)-induced disruption in stop signal task performance.
- Psychology, BiologyExperimental and clinical psychopharmacology
- 2016
CBD, when combined with Δ9-THC in clinically available dose ratios, does not exacerbate and, under restricted conditions may even attenuate, Δ9 -THC's behavioral effects.
Human Pharmacokinetic Parameters of Orally Administered Δ9-Tetrahydrocannabinol Capsules Are Altered by Fed Versus Fasted Conditions and Sex Differences.
- MedicineCannabis and cannabinoid research
- 2019
Findings may help to inform the guidelines provided by governing health bodies on the effects of cannabis, such as time to onset and duration of action, and aid health care practitioners in their prescribing practices.
Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity.
- Biology, PsychologyDrug and alcohol dependence
- 2017
References
SHOWING 1-10 OF 60 REFERENCES
Cannabidiol interferes with the effects of delta 9 - tetrahydrocannabinol in man.
- BiologyEuropean journal of pharmacology
- 1974
Influence of cannabidiol on delta‐9‐tetrahydrocannabinol effects
- MedicineClinical pharmacology and therapeutics
- 1976
Experiments investigating the possible interaction of tetrahydrocannabinol (THC) and cannabidiol (CBD), two major components of marihuana, were conducted under controlled laboratory conditions in a…
Pharmacokinetics and Pharmacodynamics of Cannabinoids
- Medicine, BiologyClinical pharmacokinetics
- 2003
Properties of cannabis that might be of therapeutic use include analgesia, muscle relaxation, immunosuppression, sedation, improvement of mood, stimulation of appetite, antiemesis, lowering of intraocular pressure, bronchodilation, neuroprotection and induction of apoptosis in cancer cells.
Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.
- Biology, PsychologyPsychopharmacology
- 1982
The results suggest that the effects of CBD, as opposed to those of delta 9-THC, might be involved in the antagonism of effects between the two cannabinoids.
Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extract.
- MedicineJournal of analytical toxicology
- 2005
The concentration ratio 11-OH-THC/THC was discussed as a criterion for distinguishing oral from inhalative cannabis consumption and was applied in a prospective pharmacokinetic study after single oral administration of 10 mg THC alone or together with 5.4 mg CBD in cannabis extract.
Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.
- Biology, MedicineDrug metabolism and disposition: the biological fate of chemicals
- 1995
CBD pretreatment resulted in large increases in AUC and t1/2 of all THC metabolites in brain, with a modest increase in A UC of THC.
Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
- Biology, MedicineBritish journal of pharmacology
- 1972
It is concluded that cannabis extract inhibits microsomal activity of mouse liver, chiefly by virtue of its cannabidiol content, and it is probable that cannabis consumption by man could lead to altered disposal of many other drugs, used in medicine or otherwise.
Cannabinoid-induced alterations in brain disposition of drugs of abuse.
- Biology, PsychologyBiochemical pharmacology
- 2001
Interactions of several cannabinoids with the hepatic drug metabolizing system.
- Chemistry, BiologyBiochemical pharmacology
- 1973
Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration.
- MedicineBiomedical & environmental mass spectrometry
- 1986
The disposition of deuterium-labelled cannabidiol, 2H2-CBD, was studied in five young men who were marihuana smokers and a four-fold difference in the availability of the compound was noted for the five subjects.