Randomized, Double-Blind, Placebo-Controlled Study About the Effects of Cannabidiol (CBD) on the Pharmacokinetics of Δ9-Tetrahydrocannabinol (THC) After Oral Application of THC Verses Standardized Cannabis Extract

@article{Nadulski2005RandomizedDP,
  title={Randomized, Double-Blind, Placebo-Controlled Study About the Effects of Cannabidiol (CBD) on the Pharmacokinetics of $\Delta$9-Tetrahydrocannabinol (THC) After Oral Application of THC Verses Standardized Cannabis Extract},
  author={Thomas Nadulski and Fritz Pragst and Gordon Weinberg and Patrik Roser and Martin Schnelle and Eva-Maria Fronk and Andreas M. Stadelmann},
  journal={Therapeutic Drug Monitoring},
  year={2005},
  volume={27},
  pages={799-810}
}
Cannabidiol (CBD) is known to modify the effects of Delta-tetrahydrocannabinol (THC) by decreasing anxiety and antagonizing other THC-effects. [] Key Method In context of the use of cannabis-based medicine extracts for therapeutic purposes, a study was performed in a double-blind and placebo-controlled cross-over design in which each of 24 volunteers (12 male and 12 female, age 18-45 years) obtained soft-gelatin capsules with 10 mg THC (THC-set), cannabis extract containing 10 mg THC +5.4 mg CBD (CAN-set) or…
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Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.
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In healthy volunteers, THC has marked acute behavioural and physiological effects, whereas CBD has proven to be safe and well tolerated.
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CBC may have preferential absorption over CBD and THC when administered together when administering together, and the dose of THC was similar to the doses of CBC, yet THC was quantifiable in fewer plasma samples than was CBC.
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The effects of cannabinoids THC and CBD when administered orally on measures of pain sensitivity, body temperature, locomotor activity, and catalepsy in male and female Sprague Dawley rats were examined.
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CBD can potentiate the psychoactive and physiological effects of THC in rats, most likely by delaying the metabolism and elimination of THC through an action on the CYP450 enzymes that metabolise both drugs.
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
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A prudent approach to improve tolerability with Spectrum Yellow oil might involve initial doses no higher than 240”mg total CBD and 10.8 mg total THC daily in divided doses, with titration upward over time as needed based on tolerability.
Cannabidiol (CBD) content in vaporized cannabis does not prevent tetrahydrocannabinol (THC)-induced impairment of driving and cognition
TLDR
Cannabis containing equivalent concentrations of CBD and THC appears no less impairing than THC-dominant cannabis, and in some circumstances, CBD may actually exacerbate THC-induced impairment.
Cannabidiol-Δ-tetrahydrocannabinol interactions on acute pain and locomotor activity
TLDR
The results suggest that CBD may enhance THC’s antinociceptive and hypolocomotive effects, primarily prolonging THC”s duration of action; however, these effects were small and inconsistent across experiments.
Acute and chronic effects of cannabidiol on Δ⁹-tetrahydrocannabinol (Δ⁹-THC)-induced disruption in stop signal task performance.
TLDR
CBD, when combined with Δ9-THC in clinically available dose ratios, does not exacerbate and, under restricted conditions may even attenuate, Δ9 -THC's behavioral effects.
Human Pharmacokinetic Parameters of Orally Administered Δ9-Tetrahydrocannabinol Capsules Are Altered by Fed Versus Fasted Conditions and Sex Differences.
TLDR
Findings may help to inform the guidelines provided by governing health bodies on the effects of cannabis, such as time to onset and duration of action, and aid health care practitioners in their prescribing practices.
Cannabidiol-Δ9-tetrahydrocannabinol interactions on acute pain and locomotor activity.
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