Randomization in clinical trials: conclusions and recommendations.

@article{Lachin1988RandomizationIC,
  title={Randomization in clinical trials: conclusions and recommendations.},
  author={John M Lachin and John P. Matts and Lee-Jen Wei},
  journal={Controlled clinical trials},
  year={1988},
  volume={9 4},
  pages={365-74}
}
The statistical properties of simple (complete) randomization, permuted-block (or simply blocked) randomization, and the urn adaptive biased-coin randomization are summarized. These procedures are contrasted to covariate adaptive procedures such as minimization and to response adaptive procedures such as the play-the-winner rule. General recommendations are offered regarding the use of complete, permuted-block, or urn randomization. In a large double-masked trial, any of these procedures may be… CONTINUE READING

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Exact two-sample permutation tests based on the randomized play-thewinner rule

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4 Excerpts

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