Randomization and resilience of brain functional networks as systems-level endophenotypes of schizophrenia.

@article{Lo2015RandomizationAR,
  title={Randomization and resilience of brain functional networks as systems-level endophenotypes of schizophrenia.},
  author={Chun-Yi Zac Lo and Tsung-Wei Su and Chu-Chung Huang and Chia-Chun Hung and Wei-Ling Chen and Tsuo-Hung Lan and Ching-Po Lin and Edward T. Bullmore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 29},
  pages={9123-8}
}
Schizophrenia is increasingly conceived as a disorder of brain network organization or dysconnectivity syndrome. Functional MRI (fMRI) networks in schizophrenia have been characterized by abnormally random topology. We tested the hypothesis that network randomization is an endophenotype of schizophrenia and therefore evident also in nonpsychotic relatives of patients. Head movement-corrected, resting-state fMRI data were acquired from 25 patients with schizophrenia, 25 first-degree relatives of… CONTINUE READING
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Genetic control of functional brain network efficiency in children

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