Randomised trial of oral aspirin for chronic venous leg ulcers

@article{Layton1994RandomisedTO,
  title={Randomised trial of oral aspirin for chronic venous leg ulcers},
  author={Alison M. Layton and Mark J. D. Goodfield and Sally Helen Ibbotson and J. Andrew Davies},
  journal={The Lancet},
  year={1994},
  volume={344},
  pages={164-165}
}
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TLDR
The findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers.
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An increased rate of venous ulcer healing with the use of oral enteric‐coated aspirin (300mg) daily has been reported.1 Whether the effect of aspirin in this condition is related to its action on the
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There was no evidence that aspirin was effective in expediting the healing of chronic VLUs, and the analysis was underpowered due to the low number of participants recruited.
Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU).
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This trial is one of three trials that will contribute to an individual participant data meta-analysis to be undertaken at the York Trials Centre and is successfully recruiting.
AVURT: aspirin versus placebo for the treatment of venous leg ulcers - a Phase II pilot randomised controlled trial.
TLDR
There was no evidence that aspirin was efficacious in hastening the healing of chronic VLUs and it can be concluded that a larger Phase III (effectiveness) trial would not be feasible.
Aspirin for Venous Ulcers: Randomised Trial (AVURT): study protocol for a randomised controlled trial
TLDR
The AVURT trial will investigate the efficacy and safety of aspirin as a treatment for VLU and will inform on the feasibility of proceeding to a larger phase III study.
Efficacy of Daflon 500 mg in Venous Leg Ulcer Healing: A Double-Blind, Randomized, Controlled Versus Placebo Trial in 107 Patients
TLDR
This study showed that a two-month course of Daflon 500 mg at a daily dose of two tablets, in addition to conventional treatment, is of benefit in patients with venous ulcer ≤ 10 cm by accelerating complete healing.
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References

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TLDR
Oxpentifylline used in conjunction with compression bandaging improves the healing of venous ulcers of the leg.
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TLDR
These prognostic factors used in a simple scoring system predict time to healing in patients with a smaller initial ulcer area and shorter duration of ulceration.
A relative thrombocytosis and elevated mean platelet volume are features of gravitational disease
TLDR
Platelet counts were significantly higher in both gravitational groups than in the EE group or the normal controls (P= 0.001), and patients with non‐gravitational ulcers had normal platelet counts.
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In view of the invasive propensities of this organism and its ability to destroy native or grafted skin, special search should be routinely made for its existence and appropriate antibiotic therapy instituted if clinically indicated.
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Results support the viewpoint of Norris and his co-authors that further studies of haemostasis in Klinefelter's syndrome are justified in order to determine whether these isolated reports of platelet hyperaggregability are related to the development of leg ulcers.