Randomised trial of oral aspirin for chronic venous leg ulcers

@article{Layton1994RandomisedTO,
  title={Randomised trial of oral aspirin for chronic venous leg ulcers},
  author={Alison M. Layton and Mark J. D. Goodfield and Sally Helen Ibbotson and J. Andrew Davies},
  journal={The Lancet},
  year={1994},
  volume={344},
  pages={164-165}
}
View on Elsevier
doi.org
109 Citations
Highly Influential Citations
1
Background Citations
21
Methods Citations
1
Results Citations
6

109 Citations

Citation Type

Citation Type

Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU)
TLDR
The findings do not support the use of low dose aspirin as adjuvant treatment for venous leg ulcers.
Aspirin in venous leg ulcer study (ASPiVLU): study protocol for a randomised controlled trial
TLDR
The ASPiVLU trial will investigate the efficacy and safety of aspirin as an adjunct to compression therapy to treat venous leg ulcers and whether 300-mg oral doses of aspirin improve time to healing.
The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration
An increased rate of venous ulcer healing with the use of oral enteric‐coated aspirin (300mg) daily has been reported.1 Whether the effect of aspirin in this condition is related to its action on the…
Aspirin versus placebo for the treatment of venous leg ulcers—a phase II, pilot, randomised trial (AVURT)
TLDR
There was no evidence that aspirin was effective in expediting the healing of chronic VLUs, and the analysis was underpowered due to the low number of participants recruited.
Low-dose aspirin as an adjuvant treatment for venous leg ulceration: study protocol for a randomized controlled trial (Aspirin4VLU).
TLDR
This trial is one of three trials that will contribute to an individual participant data meta-analysis to be undertaken at the York Trials Centre and is successfully recruiting.
AVURT: aspirin versus placebo for the treatment of venous leg ulcers - a Phase II pilot randomised controlled trial.
TLDR
There was no evidence that aspirin was efficacious in hastening the healing of chronic VLUs and it can be concluded that a larger Phase III (effectiveness) trial would not be feasible.
Aspirin for Venous Ulcers: Randomised Trial (AVURT): study protocol for a randomised controlled trial
TLDR
The AVURT trial will investigate the efficacy and safety of aspirin as a treatment for VLU and will inform on the feasibility of proceeding to a larger phase III study.
Efficacy of Daflon 500 mg in Venous Leg Ulcer Healing: A Double-Blind, Randomized, Controlled Versus Placebo Trial in 107 Patients
TLDR
This study showed that a two-month course of Daflon 500 mg at a daily dose of two tablets, in addition to conventional treatment, is of benefit in patients with venous ulcer ≤ 10 cm by accelerating complete healing.
Once daily 300 mg aspirin with compression versus compression alone in patients with chronic venous leg ulcers (ASPiVLU): A randomised, double-blinded, multicentre, placebo-controlled, clinical trial.
Influence of aspirin therapy in the ulcer associated with chronic venous insufficiency.
...
1
2
3
4
5
...

References

SHOWING 1-8 OF 8 REFERENCES
Oxpentifylline treatment of venous ulcers of the leg.
TLDR
Oxpentifylline used in conjunction with compression bandaging improves the healing of venous ulcers of the leg.
Systemic administration of antibiotics in the management of venous ulcers. A randomized clinical trial.
Venous leg ulcers: a prognostic index to predict time to healing.
TLDR
These prognostic factors used in a simple scoring system predict time to healing in patients with a smaller initial ulcer area and shorter duration of ulceration.
A relative thrombocytosis and elevated mean platelet volume are features of gravitational disease
TLDR
Platelet counts were significantly higher in both gravitational groups than in the EE group or the normal controls (P= 0.001), and patients with non‐gravitational ulcers had normal platelet counts.
The Bacteriology of Leg Ulcers
TLDR
In view of the invasive propensities of this organism and its ability to destroy native or grafted skin, special search should be routinely made for its existence and appropriate antibiotic therapy instituted if clinically indicated.
Platelet hyperggregabillity in two patients killinefelter's sundrome complicated by leg ulcers
TLDR
Results support the viewpoint of Norris and his co-authors that further studies of haemostasis in Klinefelter's syndrome are justified in order to determine whether these isolated reports of platelet hyperaggregability are related to the development of leg ulcers.
An environment for healing: The role of occlusion
Royal Society of Medicine, London