Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L'ipertensione portale (GTIP)

@article{Merkel1996RandomisedTO,
  title={Randomised trial of nadolol alone or with isosorbide mononitrate for primary prophylaxis of variceal bleeding in cirrhosis. Gruppo-Triveneto per L'ipertensione portale (GTIP)},
  author={Carlo Merkel and Renato Marin and Edda Enzo and Carlo Donada and Giorgio Cavallarin and Pierluigi Torboli and Piero Amodio and G Sebastianelli and David Sacerdoti and Martina Felder and Cesare Mazzaro and Philippe Beltrame and Angelo Gatta},
  journal={Lancet},
  year={1996},
  volume={348 9043},
  pages={1677-81}
}
BACKGROUND The risk of having a first cirrhosis-associated variceal bleed is lowered by about 50% by beta-blockers. Use of beta-blockers is currently recommended for patients with cirrhosis and oesophageal varices that are at risk of bleeding. We aimed to test the effectiveness of isosorbide mononitrate as an adjunct to the beta-blocker nadolol in the prophylaxis of first variceal bleeding in these patients. METHODS We did a randomised multicentre study to compare the non-selective beta… CONTINUE READING

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