Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation.

@article{Nikolajsen1997RandomisedTO,
  title={Randomised trial of epidural bupivacaine and morphine in prevention of stump and phantom pain in lower-limb amputation.},
  author={Lone Nikolajsen and S Ilkjaer and Jeppe H. Christensen and K. Kr\oner and Troels Staehelin Jensen},
  journal={Lancet},
  year={1997},
  volume={350 9088},
  pages={1353-7}
}
BACKGROUND Epidural analgesia before limb amputation is commonly used to reduce postamputation pain. But there have been no controlled studies with large numbers of patients to prove such a pre-emptive effect. We investigated whether postamputation stump and phantom pain in the first year is reduced by preoperative epidural blockade with bupivacaine and morphine. METHODS In a randomised, double-blind trial, 60 patients scheduled for lower-limb amputation were randomly assigned epidural… CONTINUE READING