Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

@article{Group1994RandomisedTO,
  title={Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)},
  author={Scandinavian Simvastatin Survival Study Group},
  journal={The Lancet},
  year={1994},
  volume={344},
  pages={1383-1389}
}
Drug therapy for hypercholesterolaemia has remained controversial mainly because of insufficient clinical trial evidence for improved survival. The present trial was designed to evaluate the effect of cholesterol lowering with simvastatin on mortality and morbidity in patients with coronary heart disease (CHD). 4444 patients with angina pectoris or previous myocardial infarction and serum cholesterol 5.5-8.0 mmol/L on a lipid-lowering diet were randomised to double-blind treatment with… Expand

Paper Mentions

Observational Clinical Trial
The Fast-MI registry was designed to evaluate the "real world" management of patients with acute myocardial infarction (MI), and to assess their in-hospital, medium and long-term… Expand
ConditionsAcute Myocardial Infarction
InterventionOther
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 44 REFERENCES
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin.
The Oslo Diet‐Heart Study: Eleven‐Year Report
...
1
2
3
4
5
...