Randomised prostate cancer screening trial: 20 year follow-up

@article{Sandblom2011RandomisedPC,
  title={Randomised prostate cancer screening trial: 20 year follow-up},
  author={Gabriel Sandblom and Eberhard Varenhorst and Johan Rosell and Owe L{\"o}fman and Per G. Carlsson},
  journal={The BMJ},
  year={2011},
  volume={342}
}
Objective To assess whether screening for prostate cancer reduces prostate cancer specific mortality. Design Population based randomised controlled trial. Setting Department of Urology, Norrköping, and the South-East Region Prostate Cancer Register. Participants All men aged 50-69 in the city of Norrköping, Sweden, identified in 1987 in the National Population Register (n=9026). Intervention From the study population, 1494 men were randomly allocated to be screened by including every sixth man… 
Prostate Cancer Screening: Outcomes and Risk Prediction
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The four papers included in this thesis present the outcomes of PSA-based screening and also describe aspects of the risk of PC at initial screening, during the 22-year follow-up of the programme, and after termination of screening.
Design and preliminary recruitment results of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP)
TLDR
The CAP trial successfully met its recruitment targets and will make an important contribution to international understanding of PSA-based prostate cancer screening, with little evidence of differences between trial arms in measured baseline characteristics of the consenting GP practices.
Screening for Prostate Cancer: A Review of the Evidence for the U.S. Preventive Services Task Force
TLDR
Prostate-specific antigen-based screening results in small or no reduction in prostate cancer-specific mortality and is associated with harms related to subsequent evaluation and treatments, some of which may be unnecessary.
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TLDR
The PSA test needs to be combined with other predictive factors or be used in a more thoughtful way to identify men at risk of symptomatic or life-threatening cancer, without overdiagnosing indolent disease.
Impact of Early Diagnosis of Prostate Cancer on Survival Outcomes.
Prostate Cancer Screening
TLDR
There is no justification for the introduction of population-based organized screening for prostate cancer at any age; while in view of the potential harms associated with screening, physicians should generally recommend against PSA testing for asymptomatic men.
Screening for prostate cancer: Can randomized studies optimize the trade-off between over - and under-diagnosis?
TLDR
Screening for prostate cancer may reduce prostate cancer mortality, but to the cost of over-detection and over-treatment.
Screening for prostate cancer: History, evidence, controversies and future perspectives toward individualized screening
  • Kazuto Ito, Ryo Oki, I. Kurosawa
  • Medicine
    International journal of urology : official journal of the Japanese Urological Association
  • 2019
TLDR
Countermeasures against prostate cancer could be very important not only in Western countries, but also in developed Asian countries because differences in the incidence and mortality rate of prostate cancer between the USA and Japan have been decreasing over time, and were only twofold in 2017.
Population screening for prostate cancer: An overview of available studies and meta‐analysis
TLDR
Excluding the main shortcomings in screening studies (short follow up, high prostate‐specific antigen contamination in non‐screening group and low participation in screening group), screening is able to reduce prostate cancer mortality.
Screening Coverage Needed to Reduce Mortality from Prostate Cancer: A Living Systematic Review
TLDR
The quality of evidence is downgraded to moderate due to the retrospective identification of subgroups and limited data on control group screening, and the benefit of screening for prostate cancer compares favorably with screening for other cancers.
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TLDR
PSA-based screening reduced the rate of death from prostate cancer by 20% but was associated with a high risk of overdiagnosis.
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TLDR
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TLDR
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TLDR
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