• Corpus ID: 3661837

Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea.

@article{Chatterjee2013RandomisedPD,
  title={Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated diarrhoea.},
  author={Suparna Chatterjee and Premashis Kar and Tapas Das and Sayantan Ray and Satyabrata Gangulyt and Chinnaswamy Rajendiran and Monjori Mitra},
  journal={The Journal of the Association of Physicians of India},
  year={2013},
  volume={61 10},
  pages={
          708-12
        }
}
AIMS To evaluate the effectiveness, safety and tolerability of a probiotic formulation containing Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 in the prevention of antibiotic associated diarrhoea (AAD. [] Key Method The effectiveness of a 14-day therapy (concomitant with antibiotic course and seven days thereafter) of the probiotic formulation in preventing AAD was evaluated.

Tables from this paper

Probiotics for the Prevention of Antibiotic-associated Diarrhea in Adults
TLDR
Using probiotics as early as possible during antibiotic therapy has a positive and safe effect on preventing AAD in adults, and further studies should focus on the optimal dosage and duration of probiotics to develop a specific recommendation.
Probiotics for the prevention of antibiotic-associated diarrhoea: a systematic review and meta-analysis
TLDR
Properties of probiotics, mainly of the lactobacillus and bifidobacteria genera, were found to be effective and certain species have shown increased effectiveness.
Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis
TLDR
The results suggests that probiotic use may be beneficial in the prevention of AAD among outpatients and the use of probiotics appears safe.
Effects of Probiotics Supplementation on Gastrointestinal Symptoms and SIBO after Roux-en-Y Gastric Bypass: a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
TLDR
Evaluating the effect of probiotic supplementation on gastrointestinal symptoms and small intestine bacterial overgrowth in patients after Roux-en-Y gastric bypass found it effective in reducing bloating but without influencing the development of SIBO in the early postoperative period.
Probiotics Reduce the Risk of Antibiotic-Associated Diarrhea in Adults (18-64 Years) but Not the Elderly (>65 Years): A Meta-Analysis.
TLDR
The results emerging from the meta-analysis suggested that adjunct probiotic administration is associated with a reduced risk of AAD in adults but not in elderly people.
Effectiveness of probiotics in reducing the incidence of Clostridium difficile-associated diarrhea in elderly patients: a systematic review
TLDR
Probiotics were not found to be more effective than placebo for reducing CDAD incidence in elderly hospitalized patients, and further studies are needed to evaluate the effectiveness of probiotics for CDAD prevention in this population.
Probiotics for the Prevention of Antibiotic-Associated Diarrhea
TLDR
Although adverse events have been reported for probiotics, these are broadly considered to be a safe and inexpensive preventative treatment option for AAD and other gastrointestinal disorders.
Practical Recommendations of Scientific Society for the Study of Human Microbiome and Russian Gastroenterological Association (RGA) for Probiotics in Treatment and Prevention of Gastroenterological Diseases in Adults
TLDR
The clinical efficacy of probiotics depends on the probiotic strains included in their composition and is confirmed by a comparative analysis of the results of appropriate clinical studies.
The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®
This review presents selected data on the probiotic strain Bifidobacterium animalis subsp. lactis BB-12® (BB-12®), which is the world’s most documented probiotic Bifidobacterium. It is described in
Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and Functional Foods in Treatment and Prevention of Gastroenterological Diseases in Children and Adults
Aim. The practical guidelines are intended for primary care physicians, general practitioners, paediatricians, gastroenterologists and general internists to advance the treatment and prevention of
...
...

References

SHOWING 1-10 OF 14 REFERENCES
Effect of Probiotic Lactobacillus (Lacidofil® Cap) for the Prevention of Antibiotic-associated Diarrhea: A Prospective, Randomized, Double-blind, Multicenter Study
TLDR
Although the Lacidofil® cap does not reduce the rate of occurrence of AAD in adult patients with respiratory tract infection who have taken antibiotics, the Lactobacillus group maintains their bowel habits to a greater extent than the placebo group.
Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial
TLDR
Consumption of a probiotic drink containing L casei, L bulgaricus, and S thermophilus can reduce the incidence of antibiotic associated diarrhoea and C difficile associated diarrhaoa and has the potential to decrease morbidity, healthcare costs, and mortality if used routinely in patients aged over 50.
Dose–Response Efficacy of a Proprietary Probiotic Formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for Antibiotic-Associated Diarrhea and Clostridium difficile-Associated Diarrhea Prophylaxis in Adult Patients
TLDR
The proprietary probiotic blend used in this study was well tolerated and effective for reducing risk of AAD and, in particular, CDAD in hospitalized patients on antibiotics.
Meta-Analysis of Probiotics for the Prevention of Antibiotic Associated Diarrhea and the Treatment of Clostridium difficile Disease
  • L. Mcfarland
  • Medicine, Biology
    The American Journal of Gastroenterology
  • 2006
TLDR
Three types of probiotics (Saccharomyces boulardii, Lactobacillus rhamnosus GG, and probiotic mixtures) significantly reduced the development of antibiotic-associated diarrhea.
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
TLDR
The current data are promising, but it is premature to routinely recommend probiotics for the prevention of pediatric AAD, as per protocol analysis yields treatment effect estimates that are both statistically and clinically significant.
Probiotics for the prevention of pediatric antibiotic-associated diarrhea.
TLDR
The results from 22/23 trials reporting on the incidence of diarrhea show a precise benefit from probiotics compared to active, placebo or no treatment control, and this benefit remained statistically significant in an extreme plausible situation.
Probiotics for the Prevention of Antibiotic-associated Diarrhea and Clostridium difficile Diarrhea
  • J. Katz
  • Medicine, Biology
    Journal of clinical gastroenterology
  • 2006
TLDR
A careful review of the literature supports the efficacy of S. boulardii in the prevention of antibiotic-associated diarrhea recurrent C. difficile infection in adults, whereas LGG is useful in the treatment of antibiotics- associated diarrhea in children.
Probiotics: preventing antibiotic-associated diarrhea.
TLDR
By understanding the uses, dosages, and safety of common probiotics, nurses can help educate patients and their families on the benefits of probiotics.
...
...