Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer.

@article{Bleiberg1997RandomisedPI,
  title={Randomised phase II study of cisplatin and 5-fluorouracil (5-FU) versus cisplatin alone in advanced squamous cell oesophageal cancer.},
  author={Harry Bleiberg and Thierry Conroy and Bernard Paillot and Angel Jim{\'e}nez Lacave and G B Blijham and Jacques H Jacob and Laurent Bedenne and Mo{\"i}se Namer and P de Besi and Francesca Gay and Laurence Collette and Tarek Sahmoud},
  journal={European journal of cancer},
  year={1997},
  volume={33 8},
  pages={1216-20}
}
Patients with measurable or evaluable locally advanced or metastatic squamous cell carcinoma of the oesophagus were treated with cisplatin (CDDP), 100 mg/m2, combined with 5-fluorouracil (5-FU) at a dose of 1000 mg/m2 as a continuous infusion from days 1-5 (Arm A) or with CDDP alone (Arm B). Cycles were repeated every 3 weeks. 92 patients were randomised centrally, 88 were eligible. The response rate was 35% (95% CI (confidence interval), 20-54%) in Arm A and 19% (95% CI, 8-35%) in Arm B. One… CONTINUE READING