Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer.

@article{Hazel2004RandomisedP2,
  title={Randomised phase 2 trial of SIR-Spheres plus fluorouracil/leucovorin chemotherapy versus fluorouracil/leucovorin chemotherapy alone in advanced colorectal cancer.},
  author={Guy van Hazel and Anthony Blackwell and James R. Anderson and David Price and Paul Moroz and Geoff Bower and Giuseppe Cardaci and Bruce Gray},
  journal={Journal of surgical oncology},
  year={2004},
  volume={88 2},
  pages={78-85}
}
PURPOSE Selective internal radiation therapy (SIRT) with SIR-Spheres(R) is a new technique for selectively targeting high doses of radiation to tumours within the liver. The primary objectives of this randomised trial were to compare the response rate, time to progressive disease (PD), and toxicity of a regimen of systemic fluorouracil/leucovorin chemotherapy versus the same chemotherapy plus a single administration of SIR-Spheres in patients with advanced colorectal liver metastases. The trial… CONTINUE READING