Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy.

@article{Lvi1997RandomisedMT,
  title={Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy.},
  author={Francis A L{\'e}vi and R Zidani and J. L. Misset},
  journal={Lancet},
  year={1997},
  volume={350 9079},
  pages={681-6}
}
BACKGROUND The efficacy of chemotherapy may be affected by circadian rhythms. Therefore, we tested chronomodulated infusion (administered to coincide with relevant circadian rhythms) of oxaliplatin, fluorouracil, and folinic acid compared with a constant-rate infusion method. The combination of three drugs was delivered for 5-day courses with 16-day intervals. METHODS We expected chronotherapy to increase objective response rate by 20% compared with constant-rate infusion. We tested this… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 167 extracted citations

A Study around the Clock

INTEGRADO EM MEDICINA, GABRIELA MARTINS CAETANO, ARTIGO DE REVISÃO
2014
View 4 Excerpts
Highly Influenced

Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences • 2008
View 2 Excerpts
Highly Influenced

Implications of circadian clocks for the rhythmic delivery of cancer therapeutics.

Advanced drug delivery reviews • 2007
View 2 Excerpts
Highly Influenced

Fluoropyrimidines in Cancer Therapy

CANcER DRuG DiscoVERY, Janusz Rak, FLUOROPYRIMIDINES IN CANcER
Cancer Drug Discovery and Development • 2003
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…