Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.

@article{Staessen1997RandomisedDC,
  title={Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.},
  author={Jan A Staessen and Robert H. Fagard and Lutgarde Thijs and Hilde Celis and Guramy G Arabidze and Willem H. Birkenh{\"a}ger and Christopher John Bulpitt and Peter Wilhelmus de Leeuw and Colin T. Dollery and Astrid Elizabeth Fletcher and François Forette and Gastonea Leonetti and Choudomir K Nachev and E. Timothy O'Brien and Joseph J Rosenfeld and Jos{\'e} Luis Rodicio and Jaakko Tuomilehto and Alberto Zanchetti},
  journal={Lancet},
  year={1997},
  volume={350 9080},
  pages={757-64}
}
BACKGROUND Isolated systolic hypertension occurs in about 15% of people aged 60 years or older. In 1989, the European Working Party on High Blood Pressure in the Elderly investigated whether active treatment could reduce cardiovascular complications of isolated systolic hypertension. Fatal and non-fatal stroke combined was the primary endpoint. METHODS All patients (> 60 years) were initially started on masked placebo. At three run-in visits 1 month apart, their average sitting systolic blood… CONTINUE READING