Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression. Systematic review.

@article{Stimpson2002RandomisedCT,
  title={Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression. Systematic review.},
  author={Nicola J Stimpson and Niruj Agrawal and Glyn Lewis},
  journal={The British journal of psychiatry : the journal of mental science},
  year={2002},
  volume={181},
  pages={
          284-94
        }
}
BACKGROUND About 30% of people with depression do not respond to an antidepressant at the recommended dose and can be described as having treatment-refractory depression. AIMS To summarise the findings from all randomised controlled trials (RCTs) that have assessed the efficacy of a pharmacological or psychological intervention for treatment-refractory depression. METHOD We used a systematic search strategy to identify RCTs that included adults aged 18-75 years with a diagnosis of unipolar… CONTINUE READING

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