Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants.

@article{Aydemir2011RandomisedCT,
  title={Randomised controlled trial of prophylactic fluconazole versus nystatin for the prevention of fungal colonisation and invasive fungal infection in very low birth weight infants.},
  author={Cumhur Aydemir and Şerife Suna Oğuz and Evrim Alyamaç Dizdar and Melek Akar and Yusuf Unal Sarikabadayi and Sibel Saygan and Omer Erdeve and Uğur Dilmen},
  journal={Archives of disease in childhood. Fetal and neonatal edition},
  year={2011},
  volume={96 3},
  pages={F164-8}
}
BACKGROUND Invasive fungal infections are a major cause of morbidity and mortality in preterm infants. The authors conducted the first prospective, randomised controlled trial of nystatin compared with fluconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates. METHODS During a 12-month period, all VLBW neonates were assigned randomly to receive nystatin (1 ml suspension, 100 000 U/ml, every 8 h), fluconazole (3 mg/kg body… CONTINUE READING

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