Randomised clinical trials of fish oil supplementation in high risk pregnancies

@article{Olsen2000RandomisedCT,
  title={Randomised clinical trials of fish oil supplementation in high risk pregnancies},
  author={S. Olsen and N. Secher and A. Tabor and T. Weber and J. Walker and C. Gluud},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={2000},
  volume={107}
}
Objective To test the postulated preventive effects of dietary n‐3 fatty acids on pre‐term delivery, intrauterine growth retardation, and pregnancy induced hypertension. 

Paper Mentions

Interventional Clinical Trial
A recently completed trial of weekly injections of 17 alpha hydroxyprogesterone caproate (17P) found significant effectiveness for 17P in preventing recurrent preterm birth. However… Expand
ConditionsPreterm Birth
InterventionDrug
Interventional Clinical Trial
The initial trial examined if fish oil supplementation during pregnancy could reduce the risk of pregnancy induced hypertension, intrauterine growth retardation, and preterm birth in… Expand
ConditionsIntrauterine Growth Retardation, Pregnancy Induced Hypertension, Preterm Birth
InterventionDietary Supplement
Relationship between high consumption of marine fatty acids in early pregnancy and hypertensive disorders in pregnancy
TLDR
Whether there is a relationship between maternal intake of cod‐liver oil in early and late pregnancy and hypertensive disorders in pregnancy is investigated. Expand
Relationship between dietary intake of cod liver oil in early pregnancy and birthweight
TLDR
This study aims to investigate the possible association between birth outcome and marine food and cod liver oil intake of healthy women in early pregnancy and to establish a baseline for this study. Expand
Omega‐3 supplementation during pregnancy to prevent recurrent intrauterine growth restriction: systematic review and meta‐analysis of randomized controlled trials
To evaluate the efficacy of omega‐3 supplementation during pregnancy in preventing intrauterine growth restriction (IUGR) in women with apparently uncomplicated singleton pregnancy and previous IUGRExpand
General obstetrics: Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial
TLDR
It is suggested that intake of long‐chain n‐3 fatty acids from fish oil may delay the timing of spontaneous delivery and to test if alpha‐linolenic acid, provided as flax oil capsules, shows the same effect. Expand
Does fish oil prevent preterm birth?
  • N. Secher
  • Medicine
  • Journal of perinatal medicine
  • 2007
TLDR
The only weak effect on preterm birth found in meta-analyses could be caused by the low compliance, and the fact that many women stop supplementation before term together with a fast acting effect on fish oil. Expand
Effect of diet‐ and lifestyle‐based metabolic risk‐modifying interventions on preeclampsia: a meta‐analysis
TLDR
To evaluate the effect of dietary and lifestyle interventions with the potential to modify metabolic risk factors on the risk of preeclampsia, a large number of patients with a history of high blood pressure or high cholesterol were treated with these interventions. Expand
Does fish oil prevent preterm birth?
A literature review was performed on the effect of fish oil on preterm birth in observational and randomized studies. The only weak effect on preterm birth found in metaanalyses could be caused byExpand
Omega-3 fatty acid supplementation during pregnancy: for mother, baby, or neither?
TLDR
Existing evidence from interventional studies is sparse and conflicting and should not lead to supplementation with polyunsaturated fatty acids, so media reports of children's intelligence quotients' increasing with increased intake of essential fatty acids should not be followed. Expand
The potential benefits of using fish oil in relation to preterm labor: the case for a randomized controlled trial?
From the Maternal Nutrition Group, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital andExpand
Omega-3 Fatty acids: structure, function, and relation to the metabolic syndrome, infertility, and pregnancy.
TLDR
This review focuses on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, infertility, and pregnancy. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
A randomised double blind placebo controlled trial of fish oil in high risk pregnancy
TLDR
Whether n‐3 fatty acid (EPA/DCHA) prophylaxis is beneficial in high risk pregnancies is studied to determine. Expand
Effects of fish oil supplementation in late pregnancy on blood pressure: a randomised controlled trial
TLDR
The aim is to study the effect of fish oil supplementation on blood pressure during the third trimester of pregnancy and to establish a baseline for salmon oil supplementation in women during pregnancy. Expand
The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension
TLDR
The effects of addition of 3 g eicosapentaenoic acid daily to the diet, on recurrence rate of intrauterine growth retardation and pregnancy induced hypertension in a high risk population is studied. Expand
Pregnancy induced hypertension: will treatment with dietary eicosapentaenoic acid be effective?
TLDR
A hypothesis is proposed to explain why dietary supplementation with eicosapentaenoic acid (EPA) may reverse abnormal prostaglandin metabolism, increase membrane fluidity and lower blood pressure in PIH. Expand
A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: indications from a 50-year-old controlled trial.
TLDR
A controlled trial assessing the isolated effects of fish oil in pregnancy is warranted after later controlled trials with vitamins or minerals given in the same amounts as in this trial have largely failed to show convincing effects as seen here. Expand
New biological and clinical roles for the n-6 and n-3 fatty acids.
  • H. Hansen
  • Medicine, Biology
  • Nutrition reviews
  • 1994
Four new findings of the biochemistry and biology of the essential n-6 and n-3 fatty acids have recently been demonstrated. These findings will augment current knowledge as to the role of theExpand
Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration
TLDR
Fish-oil supplementation in the third trimester seems to prolong pregnancy without detrimental effects on the growth of the fetus or on the course of labour. Expand
Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula.
TLDR
Results of this study indicate that formula enriched with soy oil or soy and marine oils containing preformed omega 3 long-chain polyunsaturated fatty acids does not induce abnormalities in growth, clotting function, erythrocyte membrane fluidity, or vitamin A or E levels in healthy very low birth weight preterm infants. Expand
Reduction of thromboxane A2 synthesis in pregnancy by polyunsaturated fatty acid supplements
TLDR
High-dose n -3 fatty acid intake in pregnancy significantly reduces maternal thromboxane A 2 synthesis, which may provide a basis for a possible role of fish oil in managing patients at risk for preeclampsia. Expand
OMEGA‐3 FATTY ACIDS IN MATERNAL ERYTHROCYTES AND RISK OF PREECLAMPSIA
TLDR
Low erythrocyte levels of omega-3 fatty acids and high levels of some omega-6 fatty acids, particularly arachidonic acid, appear to be associated with an increased risk of preeclampsia. Expand
...
1
2
3
4
5
...