Randomised clinical trials of fish oil supplementation in high risk pregnancies

  title={Randomised clinical trials of fish oil supplementation in high risk pregnancies},
  author={Sj{\'u}rǒur F Olsen and Niels Secher and Ann Tabor and Tom Weber and James J. Walker and Christian Gluud},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
Objective To test the postulated preventive effects of dietary n‐3 fatty acids on pre‐term delivery, intrauterine growth retardation, and pregnancy induced hypertension. 

Relationship between dietary intake of cod liver oil in early pregnancy and birthweight

This study aims to investigate the possible association between birth outcome and marine food and cod liver oil intake of healthy women in early pregnancy and to establish a baseline for this study.

Omega‐3 supplementation during pregnancy to prevent recurrent intrauterine growth restriction: systematic review and meta‐analysis of randomized controlled trials

To evaluate the efficacy of omega‐3 supplementation during pregnancy in preventing intrauterine growth restriction (IUGR) in women with apparently uncomplicated singleton pregnancy and previous IUGR

General obstetrics: Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial

It is suggested that intake of long‐chain n‐3 fatty acids from fish oil may delay the timing of spontaneous delivery and to test if alpha‐linolenic acid, provided as flax oil capsules, shows the same effect.

Does fish oil prevent preterm birth?

  • N. Secher
  • Environmental Science
    Journal of perinatal medicine
  • 2007
The only weak effect on preterm birth found in meta-analyses could be caused by the low compliance, and the fact that many women stop supplementation before term together with a fast acting effect on fish oil.

Effect of diet‐ and lifestyle‐based metabolic risk‐modifying interventions on preeclampsia: a meta‐analysis

To evaluate the effect of dietary and lifestyle interventions with the potential to modify metabolic risk factors on the risk of preeclampsia, a large number of patients with a history of high blood pressure or high cholesterol were treated with these interventions.

Does fish oil prevent preterm birth?

A literature review was performed on the effect of fish oil on preterm birth in observational and randomized studies. The only weak effect on preterm birth found in metaanalyses could be caused by

Omega-3 fatty acid supplementation during pregnancy: for mother, baby, or neither?

Existing evidence from interventional studies is sparse and conflicting and should not lead to supplementation with polyunsaturated fatty acids, so media reports of children's intelligence quotients' increasing with increased intake of essential fatty acids should not be followed.

The potential benefits of using fish oil in relation to preterm labor: the case for a randomized controlled trial?

From the Maternal Nutrition Group, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark, Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and

Omega-3 Fatty acids: structure, function, and relation to the metabolic syndrome, infertility, and pregnancy.

This review focuses on structure-functional relationships and the relation of omega-3s to the metabolic syndrome, infertility, and pregnancy.



A randomised double blind placebo controlled trial of fish oil in high risk pregnancy

Whether n‐3 fatty acid (EPA/DCHA) prophylaxis is beneficial in high risk pregnancies is studied to determine.

Effects of fish oil supplementation in late pregnancy on blood pressure: a randomised controlled trial

The aim is to study the effect of fish oil supplementation on blood pressure during the third trimester of pregnancy and to establish a baseline for salmon oil supplementation in women during pregnancy.

The effects of 3g eicosapentaenoic acid daily on recurrence of intrauterine growth retardation and pregnancy induced hypertension

The effects of addition of 3 g eicosapentaenoic acid daily to the diet, on recurrence rate of intrauterine growth retardation and pregnancy induced hypertension in a high risk population is studied.

A possible preventive effect of low-dose fish oil on early delivery and pre-eclampsia: Indications from a 50-year-old controlled trial

A controlled trial assessing the isolated effects of fish oil in pregnancy is warranted after later controlled trials with vitamins or minerals given in the same amounts as in this trial have largely failed to show convincing effects as seen here.

New biological and clinical roles for the n-6 and n-3 fatty acids.

  • H. Hansen
  • Medicine, Biology
    Nutrition reviews
  • 1994
Four new findings of the biochemistry and biology of the essential n-6 and n-3 fatty acids have recently been demonstrated. These findings will augment current knowledge as to the role of the


Low erythrocyte levels of omega-3 fatty acids and high levels of some omega-6 fatty acids, particularly arachidonic acid, appear to be associated with an increased risk of preeclampsia.