Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people.

@article{Arbon2015RandomisedCT,
  title={Randomised clinical trial of the effects of prolonged-release melatonin, temazepam and zolpidem on slow-wave activity during sleep in healthy people.},
  author={Emma L. Arbon and Malgorzata Knurowska and Derk-Jan Dijk},
  journal={Journal of psychopharmacology},
  year={2015},
  volume={29 7},
  pages={
          764-76
        }
}
Current pharmacological treatments for insomnia include benzodiazepine and non-benzodiazepine hypnotics targeting γ-aminobutyric acid (GABA)A receptors, as well as agonists of the melatonin receptors MT1 and MT2. Melatonin, temazepam and zolpidem are thought to exert their effect through different mechanisms of action, but whether this leads to differential effects on electroencephalogram (EEG) power spectra during sleep in middle-aged people is currently not known. To establish whether the… CONTINUE READING
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