Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

  title={Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching},
  author={Dorothy K. Hatsukami and Herbert Severson and Amanda J Anderson and R. Isaksson Vogel and Joni A. Jensen and Berry Broadbent and Sharon E Murphy and Steven G. Carmella and Stephen S. Hecht},
  journal={Tobacco Control},
  pages={267 - 274}
Background An essential component of evaluating potential modified risk tobacco products is to determine how consumers use the product and resulting effects on biomarkers of toxicant exposure. Study design Cigarette smokers (n=391) recruited in Minnesota and Oregon were randomised to either snus or 4 mg nicotine gum for 12 weeks. Participants were instructed to completely switch from cigarettes to these products. Urine samples were collected to analyse for carcinogenic tobacco-specific… 
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Although these oral products reduce exposure to CO, their ineffective abstinence symptom suppression and low acceptability may limit their viability as PREPs.
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Compared with medicinal nicotine products, snus and varenicline increased the probability of quitting smoking completely, but snus seemed to maintain nicotine dependence.
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By using snus, Swedish male smokers may increase their overall chances of abstinence and suggest that snus is not a necessary component of smoking cessation at the population level.