Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

@article{Hatsukami2015RandomisedCT,
  title={Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching},
  author={Dorothy K. Hatsukami and Herbert Severson and Amanda J Anderson and R. Isaksson Vogel and Joni A. Jensen and Berry Broadbent and Sharon E Murphy and Steven G. Carmella and Stephen S. Hecht},
  journal={Tobacco Control},
  year={2015},
  volume={25},
  pages={267 - 274}
}
Background An essential component of evaluating potential modified risk tobacco products is to determine how consumers use the product and resulting effects on biomarkers of toxicant exposure. Study design Cigarette smokers (n=391) recruited in Minnesota and Oregon were randomised to either snus or 4 mg nicotine gum for 12 weeks. Participants were instructed to completely switch from cigarettes to these products. Urine samples were collected to analyse for carcinogenic tobacco-specific… 
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