Randomised clinical trial: the long‐term safety and tolerability of naloxegol in patients with pain and opioid‐induced constipation

@article{Webster2014RandomisedCT,
  title={Randomised clinical trial: the long‐term safety and tolerability of naloxegol in patients with pain and opioid‐induced constipation},
  author={Lynn R. Webster and W. D. Chey and Jan Tack and Jaakko Lappalainen and Ulysses Diva and Mark Sostek},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={2014},
  volume={40}
}
Opioid‐induced constipation (OIC) is a common adverse effect of opioid therapy. 

▼Naloxegol for opioid-induced constipation

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The evidence for naloxegol is reviewed and its place in the management of opioid-induced constipation in adults who have had an inadequate response to laxative treatment is considered.

There is relief for constipated patients taking opioids.

A critical appraisal and clinical application of naloxegol in patients with opioid-induced constipation and laxative-inadequate response and its effectiveness and safety are evaluated.

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Naloxegol demonstrated clinical efficacy and was well tolerated in placebo-controlled trials in patients with non-cancer pain and opioid-induced constipation, including those with an inadequate response to laxatives, and wasWell tolerated in a long-term safety study.

Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study

Naldemedine significantly increased bowel movement frequency, improved symptomatic burden of opioid-induced constipation, and increased patients' quality of life vs placebo in a 52-week, randomized, double-blind, phase 3 study.

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Peripherally acting μ-opioid receptor antagonists have been clinically tested to improve bowel symptoms without compromise to pain relief, although there are associated side effects, including abdominal pain.

Clinical utility of naloxegol in the treatment of opioid-induced constipation

Naloxegol is the first orally dosed PAMORA indicated for the treatment of OIC in noncancer patients and suggests its efficacy in patients failing traditional constipation treatments; however, insufficient evidence exists to establish its role in primary prevention of OI at this time.

Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies

The data suggested that naldemedine can improve bowel function and QOL in Japanese patients with OIC receiving regular-use opioids or prolonged-release oxycodone for chronic noncancer pain.
...

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