Randomised clinical trial: the benefit of combination therapy with adefovir and lamivudine for chronic hepatitis B.

@article{Ghany2012RandomisedCT,
  title={Randomised clinical trial: the benefit of combination therapy with adefovir and lamivudine for chronic hepatitis B.},
  author={Marc G Ghany and Jordan J Feld and Xin-han Zhao and Theo Heller and Edward C Doo and Yaron Rotman and Pothuraju Nagabhyru and Christopher K. H. Koh and David E Kleiner and Elizabeth C. Wright and T. Jake Liang and Jay H. Hoofnagle},
  journal={Alimentary pharmacology & therapeutics},
  year={2012},
  volume={35 9},
  pages={1027-35}
}
BACKGROUND Combination antiviral therapy holds the promise of increasing response rates while decreasing antiviral resistance, but has yet to be shown to be beneficial or necessary in chronic hepatitis B. AIM To evaluate the benefit of combination therapy with adefovir and lamivudine versus adefovir alone in maintaining virological, biochemical and histological responses. METHODS Patients with chronic hepatitis B with and without previous lamivudine therapy were randomised to receive… CONTINUE READING