Randomised clinical trial: a placebo-controlled study of intravenous golimumab induction therapy for ulcerative colitis.

@article{Rutgeerts2015RandomisedCT,
  title={Randomised clinical trial: a placebo-controlled study of intravenous golimumab induction therapy for ulcerative colitis.},
  author={Paul J. Rutgeerts and Brian G Feagan and Colleen W. Marano and Lakshmi Padgett and Richard Strauss and Jewel Johanns and Omoniyi J. Adedokun and C. Guzzo and Hongyan Zhang and J. F. Colombel and Walter Reinisch and Peter R. Gibson and W J Sandborn},
  journal={Alimentary pharmacology & therapeutics},
  year={2015},
  volume={42 5},
  pages={504-14}
}
BACKGROUND Tumour necrosis factor alpha (TNFα)-antagonism effectively treats ulcerative colitis (UC). The golimumab clinical programme evaluated subcutaneous (SC) and intravenous (IV) induction, and SC maintenance regimens, in TNFα-antagonist-naïve patients with moderate-to-severe active UC despite conventional treatment. AIM To evaluate dose-response relationship, select IV golimumab induction doses for continued development, and evaluate the safety and efficacy of selected doses. METHODS… CONTINUE READING
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