Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms.

@article{Appleton1999RandomisedPS,
  title={Randomised, placebo-controlled study of vigabatrin as first-line treatment of infantile spasms.},
  author={Richard E. Appleton and A. C. Boudewijn Peters and John P. Mumford and David E Shaw},
  journal={Epilepsia},
  year={1999},
  volume={40 11},
  pages={1627-33}
}
PURPOSE Vigabatrin (VGB) has been shown to be an effective drug in the treatment of infantile spasms (West syndrome) in predominantly retrospective and open but also in prospective studies. This prospective, randomised, and placebo-controlled trial of VGB in infantile spasms was considered to be justified and feasible to confirm or refute these previous findings. METHODS Forty children with newly diagnosed infantile spasms received either VGB or placebo for 5 days in a double blind, placebo… CONTINUE READING

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