Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma
@article{Kon1998RandomisedDP, title={Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma}, author={Onn Min Kon and B. S. Sihra and Chris Compton and Thomas Brent Leonard and A. Barry Kay and Neil C Barnes}, journal={The Lancet}, year={1998}, volume={352}, pages={1109-1113} }
153 Citations
The Effects of a Monoclonal Antibody Directed against Tumor Necrosis Factor-α in Asthma
- Medicine, Biology
- 2006
Rationale: Neutralization of tumor necrosis factor-α (TNF-α) is an effective antiinflammatory therapy for several chronic inflammatory diseases.Methods and Objectives: We undertook a double-blind,…
The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma.
- Biology, MedicineThe European respiratory journal
- 2001
Keliximab, as an anti-CD4 monoclonal antibody, leads to a transient reduction in the number ofCD4+ T-cells and modulation of CD4+ receptor expression in severe asthmatics, in addition to a reduction in allergen-induced proliferation.
Anti-T cell strategies in asthma
- Biology, MedicineInflammation Research
- 1999
Controlled clinical trials of cyclosporin A were effective in both chronic asthma and in a model of provoked asthma, and strategies targeting T cell co-stimulatory molecules and T-cell derived cytokines may be of therapeutic utility.
Evaluation of new drugs for asthma and COPD: Endpoints, biomarkers and clinical trial designs
- Medicine, Biology
- 2004
Clinical trial designs range from studies on lung function, symptoms and exercise performance, inflammatory biomarkers, natural history of chronic stable disease, prevention and treatment of exacerbations, and effects on cachexia and muscle function to ex vivo whole blood stimulation to enable pharmacokinetic/pharmacodynamic modelling in establishing an optimal dosage regimen relatively early in human clinical studies.
The role of monoclonal antibodies in the treatment of severe asthma
- Biology, MedicineTherapeutic advances in respiratory disease
- 2011
An overview of present and future monoclonal antibody therapies for the treatment of patients with severe asthma is provided.
What is new in the management of childhood asthma?
- Medicine, BiologyIndian journal of pediatrics
- 2008
It is evident that the current ICS are already very efficient and safe, it will be difficult to introduce further improved formulations, so the most fruitful effort shall be in developing patient friendly easy to use targeted delivery systems.
Biologic therapy for atopic asthma and beyond
- Medicine, BiologyCurrent opinion in allergy and clinical immunology
- 2013
The authors will review the existing efficacy and safety data from clinical trials of some of the new biologic therapies that are in development for severe asthma.
Asthma Refractory to Glucocorticoids
- Medicine, BiologyAmerican journal of respiratory medicine : drugs, devices, and other interventions
- 2002
Meta-analysis of trials of methotrexate in oral glucocorticoid-dependent asthma have confirmed that concomitant weekly metotrexate for a minimum of 3 to 6 months enables significant (approximately 20%) overall reduction in oral glucose requirements, although only approximately 60% of patients show a significant response.
Alternative strategies in the treatment of bronchial asthma
- MedicineClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
- 2000
Bronchial asthma is a common disease, of which most patients are adequately treated by standard therapy [1]. However, a small but worrying group of patients with asthma has severe, unremitting…
What's in the pipeline? Prospects for monoclonal antibodies (mAbs) as therapies for lung diseases.
- BiologyPulmonary pharmacology & therapeutics
- 2002
The scientific rationale for generating mAb therapies directed specifically toward COPD and asthma is discussed and it is believed that as a therapeutic class, mAbs offer the opportunity to alter symptoms, progression and outcome of chronic pulmonary diseases.
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