Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate.

  title={Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate.},
  author={K. Hodge and J. McNeal and M. Terris and T. Stamey},
  journal={The Journal of urology},
  volume={142 1},
          71-4; discussion 74-5
Random systematic ultrasound guided transrectal core biopsies of the prostate were compared to directed biopsies of specific hypoechoic defects in 136 men with abnormal prostates on digital rectal examination. Prostate cancer was diagnosed in 83 of 136 patients (62 per cent). In 80 of 83 individuals (94 per cent) the cancer was detected by random systematic biopsies alone. Of 57 men in whom random systematic and directed biopsies were obtained the results of biopsy agreed in 86 per cent, while… Expand

Paper Mentions

Interventional Clinical Trial
Tranperineal prostate biopsy(TPB) and Transrectal prostate biopsy(TRUSB) are now both routine diagnosis methods of prostate cancer in Queen Mary Hospital. The TRUSB has been the most… Expand
ConditionsProstate Cancer, Prostatic Hyperplasia
Transrectal ultrasound guided biopsy of the prostate: random sextant versus biopsies of sono-morphologically suspicious lesions
Taking the endosonographic morphology of the prostate gland into consideration for biopsy strategies may improve the quality of the biopsy and avoid unnecessary invasive procedures in selected cases. Expand
Systematic transrectal ultrasound guided prostate biopsy after negative digitally directed prostate biopsy.
Results confirm the postulate that random systematic digitally directed biopsy is highly accurate in making the diagnosis of prostate cancer and suggest that performing biopsies in a systematic pattern is more important than the method used to guide the biopsy needle. Expand
Transrectal ultrasound-guided systematic 13-core prostate biopsy to diagnose prostate carcinoma
It is demonstrated that transrectal ultrasound guided systematic 13-core prostate biopsy can significantly increase the cancer detection rate, is safe and efficacious, and should be recommended for use clinically. Expand
Comparison of systematic sextant and lesion directed biopsies in prostate cancer detection.
Lesion directed biopsy increase the detection of prostate cancer when performed in addition to systematic random sextant biopsies, but they do not add to the determination of bilateral disease, nor do theyAdd to the pathologic grading of the detected cancer. Expand
Diagnosis of prostatic carcinoma: value of random transrectal sonographically guided biopsies.
Yield of carcinoma on transrectal sonographically guidedBiopsies increases significantly when segmental random biopsies are performed, and should include cores through hypoechoic lesions that are suggestive of carcinomas and bilateral segmentalrandom biopsie. Expand
The ability of systematic transrectal ultrasound guided biopsy to detect prostate cancer in men with the clinical diagnosis of benign prostatic hyperplasia.
The results suggest that multiple directed and systematic ultrasound guided biopsies are capable of detecting low volume nonpalpable prostate cancer in men with BPH, and that use of this modality is most appropriate for patients undergoing pharmacological therapy or balloon dilation of BPH rather than for those undergoing transurethral prostatectomy. Expand
Identification of residual cancer in the prostate following radiation therapy: role of transrectal ultrasound guided biopsy and prostate specific antigen.
Transrectal, ultrasound guided needle biopsies were performed in 27 men greater than 18 months (mean 5.2 years) after radiation therapy for prostate cancer and directed biopsie of hypoechoic areas were positive for cancer in 67 per cent of the cases and isoechoics areas were negative in 65 per cent. Expand
Detection of clinically significant prostate cancer by transrectal ultrasound-guided systematic biopsies.
Conservative management is recommended for patients without significant cancer on repeat biopsy in whom initial biopsies have revealed only a minute focus of cancer in 1 of the biopsy cores, and concern is also warranted for patients who have 3 mm. or less of cancer. Expand
Fine needle aspiration biopsy vs. ultrasound-guided transrectal random core biopsy of the prostate. Comparative investigations in 246 cases.
In the authors' hands, FNAB method has a sensitivity of 98%, whereas core biopsy attained 91%. Expand
Extensive repeat transrectal ultrasound guided prostate biopsy in patients with previous benign sextant biopsies.
Extensive prostate biopsy identifies significant prostate cancer in many men in whom previous sextant biopsy was benign, and should be considered when findings are suspicious for adenocarcinoma despite previously negative sextan biopsy. Expand


Ultrasound guided transrectal core biopsies of the palpably abnormal prostate.
The combination of the new spring-loaded biopsy guns and transrectal ultrasound guidance of biopsies provides the urologist with a tool that allows multiple prostate cores to be obtained safely and painlessly, reducing the sampling error and increasing the accuracy in diagnosing prostate cancer in the man with a palpable abnormality of the prostate. Expand
Morphometric and clinical studies on 68 consecutive radical prostatectomies.
It is believed that the modified nerve-sparing radical prostatectomy should be limited to the contralateral side in stage B disease. Expand
Clinical application of transrectal ultrasonography and prostate specific antigen in the search for prostate cancer.
We reviewed 225 men who were followed for 2 to 21 years by periodic rectal examination in an effort to detect prostatic cancer without the glands having been sufficiently suspicious for biopsy toExpand
Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. II. Radical prostatectomy treated patients.
No difference in preoperative or postoperative prostate specific antigen levels, cancer volume, seminal vesicle invasion or incidence of pelvic lymph node metastasis was seen, providing the first quantitative evidence that small amounts of capsular penetration may not be of biological or prognostic significance. Expand
Stage A versus stage B adenocarcinoma of the prostate: morphological comparison and biological significance.
It is proposed that stages A and B cancers are biologically similar malignancies, distinguished only by their site of origin, and both showed progressive dedifferentiation with increasing volume. Expand
Zonal Distribution of Prostatic Adenocarcinoma: Correlation with Histologic Pattern and Direction of Spread
It is concluded that carcinoma typically arises in the region of the prostate that is susceptible to benign prostatic hyperplasia and that the great majority of Stage A (TUR) cancers are transition zone cancers. Expand
Origin and evolution of benign prostatic enlargement.
  • J. McNeal
  • Biology, Medicine
  • Investigative urology
  • 1978
Quantitative analysis was applied to BPH development in 63 autopsy prostates, finding that BPH evolved through three processes: early diffuse gland growth, small nodule proliferation, and later nodule enlargement. Expand