Random sex determination: When developmental noise tips the sex balance.

  title={Random sex determination: When developmental noise tips the sex balance.},
  author={Nicolas Perrin},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={38 12},
Sex-determining factors are usually assumed to be either genetic or environmental. The present paper aims at drawing attention to the potential contribution of developmental noise, an important but often-neglected component of phenotypic variance. Mutual inhibitions between male and female pathways make sex a bistable equilibrium, such that random fluctuations in the expression of genes at the top of the cascade are sufficient to drive individual development toward one or the other stable state… CONTINUE READING
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