Random-set Methods Identify Distinct Aspects of the Enrichment Signal in Gene-set Analysis

  title={Random-set Methods Identify Distinct Aspects of the Enrichment Signal in Gene-set Analysis},
  author={Michael and A.. and Newton and Fernando and Quintana and Johan and Den and Boon and Srikumar Sengupta and Paul Ahlquist},
A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell. Knowing the enrichment of gene sets defined by functional categories, such as gene ontology (GO) annotations, is valuable for analyzing the biological signals in microarray expression data. A common approach to measuring enichment is by cross classifying genes according to membership in a functional category and membership on a selected list of… CONTINUE READING


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