Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis.

@article{Jennewein2004RandomSO,
  title={Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis.},
  author={Stefan Jennewein and Mark R. Wildung and MyDoanh Chau and Kevin Walker and Rodney B. Croteau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 24},
  pages={9149-54}
}
Biosynthesis of the anticancer drug Taxol involves 19 enzymatic steps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial methylerythritol phosphate pathway for isoprenoid precursor supply. To gain further insight about Taxol biosynthesis relevant to the improved production of this drug and to draw inferences about the organization, regulation, and origins of this complex natural product pathway, random sequencing of a cDNA library derived from Taxus… CONTINUE READING
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