Random peptide libraries: a source of specific protein binding molecules.

@article{Devlin1990RandomPL,
  title={Random peptide libraries: a source of specific protein binding molecules.},
  author={James J. Devlin and L C Panganiban and P E Devlin},
  journal={Science},
  year={1990},
  volume={249 4967},
  pages={404-6}
}
Libraries of random peptide sequences were constructed and screened to identify peptides that specifically bind to proteins. In one of these about 2 X 10(7) different 15-residue peptide sequences were expressed on the surface of the coliphage M13. Each phage encoded a single random sequence and expressed it as a fusion complex with pIII, a minor coat protein present at five molecules per phage. Phage encoding nine different streptavidin-binding peptide sequences were isolated from this library… CONTINUE READING

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