Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy

  title={Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy},
  author={Julie Marie Gottselig and Martin Adam and Julia V. R{\'e}tey and Ramin Khatami and Peter Achermann and Hans-Peter Landolt},
  journal={Journal of Sleep Research},
Neurophysiological and functional imaging studies have demonstrated that frontal regions of the brain are particularly responsive to homeostatic sleep pressure. Previous neuropsychological studies indicate that sleep deprivation causes impairments in prefrontal cortical function. Random number generation (RNG) is thought to provide a sensitive index of executive functions that rely on the prefrontal cortex. The present study tested the hypothesis that sleep deprivation would impair RNG and that… 
Caffeine protects against increased risk‐taking propensity during severe sleep deprivation
It is suggested that 3 nights of total sleep deprivation led to a significant increase in behavioral risk‐taking but not self‐reported perception of risk‐propensity, and overnight caffeine prevented this increase in risky behavior.
Effects of sleep deprivation on dissociated components of executive functioning.
The results challenge the prevailing view that executive functions are especially vulnerable to sleep loss and question the idea that impairment due to sleep deprivation is generic to cognitive processes subserved by attention.
Adenosinergic Mechanisms Contribute to Individual Differences in Sleep Deprivation-Induced Changes in Neurobehavioral Function and Brain Rhythmic Activity
The effects of sleep deprivation and caffeine on sustained attention and regional EEG power in waking and sleep were inversely related and suggest that adenosinergic mechanisms contribute to individual differences in waking-induced impairment of neurobehavioral performance and functional aspects of EEG topography associated with sleep deprivation.
Effects of sleep deprivation on cognition.
Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil.
Although comparisons across tasks cannot be made due to the different times of administration, within-task comparisons suggest that, at the doses tested here, each stimulant may produce differential advantages depending on the cognitive demands of the task.
The effects of 53 hours of sleep deprivation on moral judgment.
It is suggested that sleep deprivation impairs the ability to integrate emotion and cognition to guide moral judgments, although susceptibility to the effects of sleep loss on this ability is moderated by the level of emotional intelligence.
Sex Differences in Cognitive Estimation During Sleep Deprivation: Effects of Stimulant Countermeasures
Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization.
Caffeine improves the efficiency of planning and sequencing abilities during sleep deprivation.
To examine whether repeated moderate doses of caffeine would effectively sustain performance on the Tower of London (TOL), a classic test of visuospatial planning and sequencing that is mediated extensively by the dorsolateral prefrontal cortex, 24 healthy participants underwent 3 nights of sleep deprivation in a laboratory setting.
Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics.
The available evidence suggests that adenosinergic mechanisms, in particular adenosine A2A receptor-mediated signal transduction, contribute to waking-induced impairments of attentional processes, whereas additional mechanisms must be involved in higher-order cognitive consequences of sleep deprivation.
Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals.
It is indicated that consumption of a caffeine-containing food supplement improves subjective state and cognitive performance in fatigued individuals that is likely a result of its caffeine content.


[Inhibition and working memory: effect of acute sleep deprivation on a random letter generation task].
The inhibition function, as measured during the performance of a brief task, seems to remain intact during an extended, 36-hour waking period, and the working-memory inhibition executive function shows greater resistance to acute sleep deprivation than does psychomotor reaction time for theperformance of short tasks.
Sleep Loss and Temporal Memory
  • Y. HarrisonJ. Horne
  • Psychology, Biology
    The Quarterly journal of experimental psychology. A, Human experimental psychology
  • 2000
It is shown that sleep deprivation impairs temporal memory (i.e. recency) despite other conditions promoting optimal performance, and caffeine was used to reduce “sleepiness”.
Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity
Evidence is provided that short‐term sleep deprivation produces global decreases in brain activity, with larger reductions in activity in the distributed cortico‐thalamic network mediating attention and higher‐order cognitive processes, and is complementary to studies demonstrating deactivation of these cortical regions during NREM and REM sleep.
Altered brain response to verbal learning following sleep deprivation
It is shown that there are dynamic, compensatory changes in cerebral activation during verbal learning after sleep deprivation and the PFC and parietal lobes are implicated in this compensation.
Effects of a new slow release formulation of caffeine on EEG, psychomotor and cognitive functions in sleep‐deprived subjects
It is demonstrated that a single dose of caffeine SR possesses alerting effects which are able to reverse the deleterious effect of 36 h sleep deprivation for at least 24 h.
Sleep deprivation-induced reduction in cortical functional response to serial subtraction.
Data from the serial subtraction task are consistent with Horne's PFC vulnerability hypothesis but, based on this and other studies, it is suggested the localized, functional effects of SD in the brain may vary, in part, with the specific cognitive task.
Changes in cognitive processing following short-term cumulative partial sleep deprivation and recovery oversleeping
Abstract The effects on cognitive processing of 1 and 5 cumulative nights of partial sleep deprivation (PSD) and 1 and 2 nights of subsequent recovery oversleep was studied using an anagrams test and
Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training
Even in the most adverse circumstances, moderate doses of caffeine can improve cognitive function, including vigilance, learning, memory, and mood state, and a dose of 200 mg appears to be optimal under such conditions.
The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.
It appears that even relatively moderate sleep restriction can seriously impair waking neurobehavioral functions in healthy adults, and sleep debt is perhaps best understood as resulting in additional wakefulness that has a neurobiological "cost" which accumulates over time.
Sleep deprivation affects speech.
There was a significant reduction in the subjects' use of appropriate intonation in the voice after SD, with subjects displaying more monotonic or flattened voices.