Random biopsy during high-resolution anoscopy increases diagnosis of anal high-grade squamous intraepithelial lesions.

@article{Silvera2014RandomBD,
  title={Random biopsy during high-resolution anoscopy increases diagnosis of anal high-grade squamous intraepithelial lesions.},
  author={Richard J Silvera and Michael M Gaisa and Stephen E. Goldstone},
  journal={Journal of acquired immune deficiency syndromes},
  year={2014},
  volume={65 1},
  pages={
          65-71
        }
}
OBJECTIVE Random biopsy (RB) of normal appearing cervix during colposcopy increases high-grade dysplasia (HSIL) diagnosis but has not been studied in high-resolution anoscopy (HRA), that is, colposcopy transferred to the anal canal. We investigated the utility of RB during HRA. DESIGN At HRA, the anal canal was divided into 4 quadrants. Areas suspicious for HSIL had standard biopsy (SB); random biopsies were taken from quadrants without apparent HSIL. Inclusion required ≥1 RB. Two providers… CONTINUE READING

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